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Inside a modern review, we documented the identification as well as the characterization of a new atypical opioid receptor with unique destructive regulatory Houses in the direction of opioid peptides.1 Our final results showed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a broad-spectru